Platelet Dysfunction Associated With Immune-Mediated Thrombocytopenia in Dogs
نویسندگان
چکیده
منابع مشابه
Platelet size, platelet surface-associated IgG, and reticulated platelets in dogs with immune-mediated thrombocytopenia.
Immune-mediated thrombocytopenia (IMT) is a disorder in which bound IgG on the surface of platelets results in platelet removal and alterations in mean platelet volume. Using flow cytometry, alterations in platelet size, platelet surface-associated IgG (PSAIgG), and numbers of reticulated platelets were determined in 13 dogs with primary IMT and 4 dogs with secondary IMT induced by experimental...
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Three dogs presented with refractory immune-mediated thrombocytopenia (IMT). All patients failed to respond to prednisone, which is considered a mainstay of immunosuppressive therapy. Vincristine-loaded platelets (VLPs), which act selectively on mononuclear phagocytes,were introduced. After the VLPs were transfused, two dogs responded quickly with improved clinical signs while the third dog wit...
متن کاملPlatelet Volume and Plateletcrit in Dogs with Presumed Primary Immune‐Mediated Thrombocytopenia
BACKGROUND Mean platelet volume (MPV) and plateletcrit (PCT) are indices used in evaluating immune-mediated thrombocytopenia (IMT) in humans and in dogs with congenital macrothrombocytopenia. These indices may provide clinically valuable information in acquired thrombocytopenia. HYPOTHESIS/OBJECTIVES Dogs with presumed primary IMT will have increased MPV, and therefore platelet mass (PCT) wil...
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BACKGROUND Immune thrombocytopenia (ITP) in dogs is analogous to that in humans. Romiplostim, a novel thrombopoietin receptor (TPO-R) agonist, is currently used for the treatment of refractory ITP in humans, but not in dogs. Here, we describe the response to romiplostim in five dogs with refractory ITP. Five dogs with severe and refractory ITP (three primary and two secondary) received romiplos...
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ژورنال
عنوان ژورنال: Journal of Veterinary Internal Medicine
سال: 1994
ISSN: 0891-6640,1939-1676
DOI: 10.1111/j.1939-1676.1994.tb03244.x